Scientists restored young gut bacteria in aging mice and saw signs of rejuvenation along with complete protection from liver cancer. Returning the gut microbiome to a more youthful state could help slow aging and lower the risk of liver cancer, according to research entitled “Restoration of a youthful gut microbiome reduces liver aging and suppresses [...]

An asthma drug called formoterol may help reverse MASH-related liver damage, prompting new clinical trials after promising results in mice and observational human studies. Researchers at the Medical University of South Carolina are investigating new ways to treat MASH, or metabolic dysfunction-associated steatohepatitis, a serious liver disease that affects hundreds of millions of people…

A new study suggests that Resmetirom may do more than treat fatty liver disease — it could also help stop liver cancer from developing. Resmetirom, a drug approved by the U.S. Food and Drug Administration (FDA) to treat metabolic dysfunction associated fatty liver disease (MAFLD), may offer benefits beyond reducing liver fat and fibrosis, according [...]

Scientists have uncovered why severely damaged livers can continue failing even after a person stops drinking alcohol. The human liver is famous for its ability to regenerate. Ancient myths even referenced its seemingly endless capacity to heal. But in people with severe alcohol-related liver disease, that recovery system can suddenly fail, leaving the organ unable [...]

Researchers have uncovered evidence that a common “sugar-free” sweetener may mimic some of fructose’s harmful effects in the body. That “sugar-free” snack in your kitchen may not be as harmless as it looks. Scientists are raising new concerns about sorbitol, a common sweetener used in products marketed as low-calorie or diabetic friendly. New research suggests [...]

An AI-powered blood test that analyzes DNA fragments could detect silent liver disease long before symptoms begin. Scientists at the Johns Hopkins Kimmel Cancer Center have developed an artificial intelligence (AI) powered liquid biopsy that may identify liver fibrosis and cirrhosis long before symptoms appear. The test studies genome-wide patterns of cell-free DNA (cfDNA) fragments [...]

A hidden molecular switch linked to liver disease may be reversible, using an unexpected, familiar compound. About 30% of people worldwide are affected by metabolic-associated fatty liver disease (MASLD), a condition closely tied to obesity and type 2 diabetes that can quietly progress to liver damage. Despite its growing impact, treatment options remain limited. New [...]

Researchers have identified a small-molecule compound that appears to counteract weight gain and metabolic damage in mice exposed to a long-term Western diet. A drug candidate developed by researchers at The University of Texas Health Science Center at San Antonio kept mice from becoming obese even after long-term exposure to a sugar-rich, fat-heavy Western diet. [...]

Scientists are exploring a new way to treat familial hypercholesterolemia. Scientists are rethinking how to treat a widespread genetic cholesterol disorder by targeting particle production instead of removal. Familial hypercholesterolemia (FH) disrupts one of the body’s most important cleanup systems. Normally, low-density lipoprotein (LDL), often called “bad” cholesterol, is removed from the…

A new study suggests that suppressing a cellular enzyme long considered protective against fatty liver disease could have unexpected long-term consequences. Scientists have uncovered a troubling tradeoff in the liver. An enzyme called Caspase-2 has attracted attention as a possible target for fatty liver disease, but new evidence suggests shutting it down could make the [...]

A new study explores how decreased testosterone and high fructose intake may interact to influence the development of fatty liver disease. Low testosterone can lead to several health issues, and poor dietary habits may further worsen these conditions. One example is metabolic dysfunction-associated steatotic liver disease (MASLD), a growing global health concern that currently affects [...]

CBD and CBG may help the liver recharge and clean itself—offering a promising new plant-based strategy against fatty liver disease. Scientists have found that two non-intoxicating compounds from cannabis, CBD and CBG, may help reduce fat buildup in the liver while improving overall metabolic health. The research shows that these compounds support the liver in [...]

A rare dual heart and liver transplant gave an 11-year-old girl a new chance at life. Children’s Hospital Colorado (Children’s Colorado) has carried out its first combined heart and liver transplant, marking a major milestone for the hospital. The highly complex procedure required coordination among dozens of specialists representing 25 multidisciplinary teams. Across the United [...]

Scientists have identified a hidden barrier that prevents immunotherapy from working against a rare liver cancer. Immunotherapy, which activates the body’s own immune system to kill cancer cells, has transformed treatment for some cancers, but it has largely fallen short against a rare, aggressive liver tumor called fibrolamellar carcinoma. A Cornell University team now reports [...]

A long-standing mystery in bile acid biology has been solved. Bile acids are often introduced as digestion helpers, but they are also powerful chemical messengers that help coordinate metabolism throughout the body. To do their jobs, these cholesterol-derived molecules must be shuttled efficiently between the liver, the intestine, and the blood in a recycling loop [...]

New research shows that reducing dietary protein may significantly lower liver cancer risk or slow its progression in people with impaired liver function For people living with liver damage, food choices can matter in ways that go beyond weight or cholesterol. A Rutgers-led team reports that dialing back protein intake could potentially lower the odds [...]