Traditionally thought to be the result of a suite of issues, the world's most common type of arthritis – osteoarthritis (OA) – actually has a single core driver. These findings, in the largest study of patients with knee OA, has the potential to make drug trials and treatment more targeted and effective.
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Category: Chronic Pain, Illnesses and conditions, Body and…
Traditionally thought to be the result of a suite of issues, the world's most common type of arthritis – osteoarthritis (OA) – actually has a single core driver. These findings, in the largest study of patients with knee OA, has the potential to make drug trials and treatment more targeted and effective.
Continue Reading
Category: Chronic Pain, Illnesses and conditions, Body and…
Researchers have identified the SHP protein as a key regulator that suppresses cartilage-degrading enzymes and slows osteoarthritis progression. For millions of people living with osteoarthritis, treatment options have long focused on one thing: managing pain. But while medications and injections may temporarily ease aching knees and stiff fingers, they do little to stop the slow [...]
A sweeping analysis of nearly 10,000 patients challenges assumptions about how best to treat knee osteoarthritis. For many people with knee osteoarthritis, relief may not require medication. A large new analysis suggests that simple physical treatments can ease pain and improve movement, often more effectively than some high-tech options. Knee osteoarthritis is one of the [...]
Researchers have uncovered a previously unobserved presence of the GLP-1 hormone in the joints of arthritis patients. Arthritis is not a single disease but a broad category of joint disorders that includes autoimmune conditions like rheumatoid arthritis and psoriatic arthritis, as well as degenerative diseases such as osteoarthritis. Despite their differences, many forms share common [...]
Overlooked plant compounds may quietly hold new clues for treating some of the most challenging forms of pain. Researchers at the University of Arizona Health Sciences say compounds from Cannabis sativa may help ease two difficult types of pain: fibromyalgia and pain after surgery. Their findings, published in Pharmacological Reports, suggest that terpenes could offer [...]
A new study shows a strong link.
A hidden process in the brain may quietly decide whether long-term pain results in resilience or depression. Scientists have identified a brain process that may explain why chronic pain leads to depression in some people but not others, according to a study published in Science. The results challenge the assumption that long-term pain inevitably results [...]
Scientists have identified a previously unknown brain circuit that appears to drive chronic pain, separate from the pathways responsible for immediate, protective pain responses. A newly mapped brain circuit tied specifically to chronic pain could open the door to better treatments for the nearly 60 million Americans affected by long-term pain, according to a study [...]
A newly identified brain circuit may hold the key to understanding why some pain fades while other pain lingers long after injury. A small, little-known region of the brain may hold the switch that determines whether pain fades or lingers for months or even years. New research from the University of Colorado Boulder suggests that [...]
Hormone-regulated immune cells produce IL-10 to resolve pain more effectively in males, offering a potential new target for non-opioid chronic pain treatments. Chronic pain often lingers longer in women than in men. A new study suggests that differences in immune cells known as monocytes could be a key reason. These cells are regulated in part [...]
Chronic back pain may reshape how the brain processes more than just signals from the spine. People living with chronic back pain may experience ordinary sounds as unusually intense, according to new research from the University of Colorado Anschutz. The study, published in Annals of Neurology, links this increased sound sensitivity to measurable differences in [...]
The largest review of its kind suggests opioids may offer far less relief for acute pain than commonly believed. The largest analysis ever conducted on opioid pain medications used for acute pain has found that these drugs offer only modest, short-lived relief for certain conditions and do not work at all for others. Researchers at [...]
Researchers have identified a bone-driven signaling pathway that may explain how spinal degeneration leads to chronic pain. Low back pain (LBP) ranks among the most widespread health conditions across the globe. It affects people at every stage of life and creates a significant strain on healthcare systems. For many individuals, the pain becomes long-lasting, disrupting [...]