Scientists have uncovered new evidence that the gut may play a far more active role in multiple sclerosis than previously recognized. For decades, multiple sclerosis (MS) has been viewed primarily as a disease of the brain and spinal cord. But growing evidence suggests its origins may begin much farther away: in the gut. Scientists have [...]

Autoantibodies may be disabling one of the body's anti-inflammatory brakes in some IBD patients, a new study finds.

A new study overturns long-held assumptions about the cause of the rare inflammatory disorder MKD, identifying a previously overlooked immune defect. Why does a routine infection trigger dangerous inflammation in some people? Researchers studying mevalonate kinase deficiency (MKD), a rare inherited autoinflammatory disorder, may have finally found the answer. Scientists at the Garvan Institute of…

Scientists identified an autoimmune mechanism linked to a major IBD risk gene, opening the door to targeted diagnosis and personalized therapies for thousands of patients. For decades, inflammatory bowel disease (IBD) has been treated as a single disorder, even though patients often experience dramatically different symptoms, disease courses, and responses to therapy. A new study [...]

As vaccination rates decline, biotech companies see a potential new market for measles drugs.

A woman developed bright-red rashes on her back that looked like marks from a whip, and at first, it wasn't clear what caused them.

Researchers identified key differences between two widely used multiple sclerosis models, showing how each can better study myelin damage, immune responses, and repair. The findings may improve efforts to develop treatments that restore lost myelin. More than 1 million people in the United States are living with multiple sclerosis (MS), a disease that damages the [...]

A massive single-cell study has revealed hidden genetic differences in male and female immune systems that may shape disease risk in unexpected ways. New research from the Garvan Institute of Medical Research and UNSW Sydney may help explain why women are far more likely than men to develop autoimmune diseases, including lupus. Autoimmune diseases occur [...]

A study of a few patients, to be presented this week, showed promise for a type of therapy that has already cured some blood cancers.

Researchers found that certain immune cells, genes, and the drug metformin may help keep HIV dormant after treatment stops, offering new paths toward long-term control. For millions of people living with HIV, taking daily medication is essential for life. If treatment stops, the virus typically returns within weeks. However, some rare individuals can control the [...]

Physical activity helps prevent cancer through improved body regulation and reduced inactivity, with even modest increases in movement making a difference. Getting into a workout routine is not always easy. Motivation can be low, time feels limited, and results may seem far off. But beyond fitness or weight loss, regular movement offers a powerful and [...]

A teen went to the emergency room with classic signs of diabetes, but odd aspects of her case pointed to a second, rarer diagnosis.

A known cell-death protein turns out to quietly reshape stem cell aging. As people grow older, the body’s ability to maintain healthy blood and a strong immune system gradually weakens. A major reason is the decline of hematopoietic stem cells (HSCs), which are responsible for producing all types of blood cells. Under normal conditions, HSCs [...]

A healthy thymus in adults is tied to longer life, reduced disease risk, and improved cancer treatment response. Two new studies from researchers at Mass General Brigham are challenging the long-standing belief that the thymus becomes unimportant after childhood. By using artificial intelligence (AI) to review standard CT scans, scientists found that adults with a [...]

Researchers have identified a promising new strategy to treat autoimmune diseases by targeting a specific molecular interaction within immune cells. Scripps Research scientists have created a new group of drug compounds that reduce harmful inflammation without weakening the body’s ability to fight infections, a major challenge in treating autoimmune diseases. These compounds, known as…

A brief sauna session may quietly mobilize the immune system. A sauna session may do more than raise your heart rate and body temperature. A new study from Finland found that it also briefly increases the number of white blood cells moving through the bloodstream, a shift tied to the body’s frontline immune defenses. The [...]

Keratin has been linked to skin diseases and inflammation in the past, but now, a new study may have uncovered one reason why.

Researchers have found that common food ingredients can interact inside immune cells in ways that significantly enhance each other’s anti-inflammatory effects. Chronic inflammation often develops quietly, without obvious symptoms in its early stages. Over time, however, this persistent immune activity can contribute to serious health conditions, including type 2 diabetes, cardiovascular disease,…

The findings suggest that vitamin B3 may help strengthen and restore a weakened immune system. Edward Waldner knew something was wrong. At 55 years old, he felt constantly drained. No matter how much he rested, the fatigue lingered. He began to question whether sleep apnea might be the cause. He also noticed subtle changes in [...]

Researchers have uncovered a previously hidden “internal brake” on immune cells that limits their ability to fight cancer, independent of tumor influence. Scientists developing next-generation cancer immunotherapies have uncovered a hidden weakness inside the immune system itself. A molecule known as SLAMF6, found on T cells, acts as a built-in shutoff switch that limits their [...]

Intestinal viruses can activate immune cells that regulate carbohydrate metabolism, highlighting an overlooked role of the gut virome, a study in mice finds.

A bandage-like microneedle patch can noninvasively collect immune cells and signals from the skin within minutes to hours. Early tests suggest it could transform how immune responses are monitored. Researchers at The Jackson Laboratory (JAX), working with the Massachusetts Institute of Technology (MIT), created the first bandage-like microneedle patch designed to sample immune activity directly…