Researchers have demonstrated a promising new approach to stopping pancreatic cancer before it starts, using experimental drugs to eliminate microscopic precancerous lesions in the pancreas. A new preclinical study in mice suggests that precancerous pancreatic cells can be removed before they progress into tumors. An experimental treatment aimed at microscopic precancerous lesions in the pancreas…

UCLA researchers gave T cells a protected supply of sugar, allowing them to attack solid tumors more effectively. UCLA researchers have developed a way to give immune cells a fuel supply that tumors cannot take away, sharply improving how well those cells survived and attacked solid tumors in preclinical experiments. The method, reported in the [...]

A new study reveals a possible way to make CAR T-cell therapy more durable and effective by targeting a single gene-regulating protein. CAR T-cell therapy is widely seen as a breakthrough in personalized cancer care. The treatment works by modifying a patient’s own immune cells so they can identify and attack cancer cells. Although the [...]

Regular movement may help lower cancer risk, and even small increases in activity can be beneficial. For many people, starting an exercise routine can feel intimidating or easy to put off. But scientists continue to uncover evidence that regular physical activity does far more than improve strength or heart health — it may also help [...]

Intravenous vitamin C may help fight cancer and reduce treatment side effects, though it remains experimental. Linus Pauling’s theory was flawed but partly correct. Few scientists shaped modern chemistry as profoundly as Linus Pauling. The American researcher won two Nobel Prizes and helped uncover the nature of chemical bonds and the structure of proteins, achievements [...]

A new study suggests that Resmetirom may do more than treat fatty liver disease — it could also help stop liver cancer from developing. Resmetirom, a drug approved by the U.S. Food and Drug Administration (FDA) to treat metabolic dysfunction associated fatty liver disease (MAFLD), may offer benefits beyond reducing liver fat and fibrosis, according [...]

A common blood pressure drug may help a major class of cancer therapies work far better than expected. A widely prescribed blood pressure drug may have an unexpected second life as a cancer therapy booster. Researchers at Dartmouth Cancer Center (DCC) have discovered that telmisartan, an FDA-approved medication commonly used to treat hypertension, can significantly [...]

Researchers have uncovered an unexpected weakness in pancreatic cancer involving damaged mitochondria and a powerful inflammatory signal. Researchers at The Wistar Institute and ChristianaCare’s Helen F. Graham Cancer Center & Research Institute have identified a weakness in pancreatic cancer that may open the door to new treatments. Their study, published in the Proceedings of the [...]

A new mathematical study explores how evolutionary principles could help doctors stay ahead of treatment-resistant cancers. A new study suggests that improving the timing of cancer treatments could help increase cure rates. The study’s principal investigator, Dr. Robert Noble, Senior Lecturer at the Department of Mathematics, City, St George’s, University of London, focused on a [...]

A newly developed therapy inspired by bacteria residing within tumors offers a different way to combat cancer by targeting how tumor cells produce energy. Researchers at the University of Illinois Chicago have designed a new cancer treatment by borrowing a strategy from bacteria that live inside tumors. Instead of attacking cancer cells directly, the approach [...]

A single-cell platform reveals that many genetic mutations converge on shared cellular programs, pointing to simpler, more unified treatment strategies. What if hundreds of different genetic mutations could all be traced back to the same hidden control switches inside a cell? Diseases such as cancer and neurodegenerative disorders are driven by a tangled web of [...]

A newly identified weakness in “zombie” cells may open the door to more precise cancer treatments by turning their own survival strategy against them. A new class of drugs takes advantage of a recently discovered weakness in “zombie-like” or senescent cells, opening the door to potential treatments for cancer and age-related diseases. Researchers from the [...]

Cancer incidence is increasing, especially among younger adults, and current risk factors don’t fully account for the trend. Scientists suggest other underlying causes may be contributing. Cancer patterns in England are shifting in a way that is drawing growing attention from researchers. While cancer has long been more common in older adults, new data show [...]

A dermatologist says there are safer alternatives to biotin for treating hair loss related to cancer. Hair loss is one of the most visible and emotionally difficult side effects of cancer treatment. For many patients, it affects identity, confidence, and a sense of normalcy. In search of solutions, some turn to biotin supplements, often promoted [...]

A surprising backup system in the immune response to mRNA vaccines may hold the key to more effective cancer treatments. The arrival of mRNA vaccines against SARS-CoV-2 in 2020 marked a turning point in the COVID-19 pandemic. Today, this Nobel Prize-winning technology is being adapted for cancer treatment. Researchers are testing mRNA vaccines in clinical [...]

A common medication may be taking on an unexpected role in cancer care. What if a cheap, everyday painkiller could help keep cancer from coming back after surgery? New clinical trial results suggest that for some patients with colorectal cancer, aspirin may do exactly that. In a study led by researchers at Karolinska Institutet and [...]

Cancer cells may “learn” to survive therapy by rewiring gene activity using AP-1 proteins. Researchers at NYU Langone Health say cancer cells may have a far more flexible survival system than scientists once thought. In a new model, the team argues that some tumors may not need to wait for rare DNA mutations to escape [...]

New research provides compelling evidence that Barrett’s esophagus underlies all cases of esophageal adenocarcinoma, even when it is no longer visible. Scientists have uncovered the clearest evidence yet that Barrett’s esophagus is the origin of all cases of esophageal adenocarcinoma, the most common form of esophageal cancer in developed countries, even when visible signs of [...]

A new experimental approach is rethinking how cancer treatments reach their targets. Mayo Clinic scientists are exploring an unusual but promising strategy to treat one of the deadliest bile duct cancers by turning milk into a microscopic delivery system for gene therapy. Their work focuses on cholangiocarcinoma, a rare cancer that is often diagnosed late [...]

MethylScan is a low-cost blood test that detects cancers and organ diseases by analyzing DNA methylation, improving early diagnosis, and identifying disease origin. UCLA researchers have created a simple, low-cost blood test that may be able to detect multiple cancers, liver diseases, and organ abnormalities at the same time by analyzing DNA fragments circulating in [...]

Young cancer patients with private insurance survive longer due to better access to care and treatment. Coverage instability worsens outcomes, but policy changes could help. Cancer is no longer just a disease of older adults. Diagnoses among teenagers and young adults have been climbing steadily over the past decade, raising new concerns about how this [...]

A bacterium from frog gut microbiota eliminated tumors in mice by selectively colonizing tumors and triggering both direct cell killing and immune-driven anticancer responses. Researchers led by Prof. Eijiro Miyako at the Japan Advanced Institute of Science and Technology (JAIST) have identified a bacterium with striking anticancer potential. The microorganism, Ewingella americana, was isolated…

The findings suggest that vitamin B3 may help strengthen and restore a weakened immune system. Edward Waldner knew something was wrong. At 55 years old, he felt constantly drained. No matter how much he rested, the fatigue lingered. He began to question whether sleep apnea might be the cause. He also noticed subtle changes in [...]

Researchers have uncovered an early survival response in ovarian cancer cells that may limit the effectiveness of widely used PARP inhibitors. A new study from Mayo Clinic researchers reports that ovarian cancer cells can quickly switch on a survival response after treatment with PARP inhibitors. Blocking this early reaction may help these drugs work more [...]

Researchers have uncovered a previously hidden “internal brake” on immune cells that limits their ability to fight cancer, independent of tumor influence. Scientists developing next-generation cancer immunotherapies have uncovered a hidden weakness inside the immune system itself. A molecule known as SLAMF6, found on T cells, acts as a built-in shutoff switch that limits their [...]

A tiny implant may give cancer-fighting immune cells the boost they need to keep working longer. Immunotherapy has changed cancer care by turning the immune system into a weapon against disease. But there is a major weakness in that strategy: many lab-engineered immune cells lose momentum soon after they enter the body. That problem is [...]

Cancer’s strongest gene switches push DNA into damaging overdrive, creating repeated breaks and repairs that may fuel tumor evolution while exposing possible therapeutic weak spots. A new study indicates that cancer can harm its own genetic material by forcing critical genes to work at unusually high levels. Scientists discovered that some of the strongest genetic [...]

Scientists turned bacteria into tumor-hunting drug factories—hinting at a bold new way to fight cancer. Millions of people worldwide are diagnosed with cancer each year, yet treating the disease remains challenging due to its complexity. New research published today (March 17) in the open-access journal PLOS Biology by Tianyu Jiang at Shandong University in Qingdao, [...]

A triple drug approach that blocks the KRAS pathway at three points eliminated pancreatic tumors and prevented resistance in mouse models. Existing treatments for pancreatic cancer often stop working within a few months because tumors quickly develop resistance to the drugs. Researchers at Spain’s National Cancer Research Centre (CNIO) report that they have prevented this [...]

Scientists have developed an AI system that analyzes complex gene-expression signatures to estimate the likelihood that a tumor will spread. Why do some tumors spread throughout the body while others remain confined to their original location? Scientists still do not fully understand the processes that determine whether cancer cells gain the ability to metastasize. Yet [...]