_Benchmarking the Honesty of Fine-Mapping Credible Sets_
Fine-mapping has a promise built into its output, and almost nobody checks whether the promise is kept.
When you run SuSiE on a GWAS locus, it hands you a _credible set_ : a small group of variants that, at a stated confidence level like 95%, should contain the true causal variant. That 95% is a claim about reality. Among all the loci…
__Build a real spatial transcriptomics pipeline on Visium mouse brain, then go one step past every tutorial: use persistent homology to find spatial structure that Moran's I misses. Every number here is reproducible from a fresh clone.__
Most spatial transcriptomics tutorials end at the same place. You load a Visium dataset, run Moran's I, colour a few genes on the tissue, and admire the…
SeqBench is a free, browser-based bioinformatics toolkit designed for molecular biologists, bioinformaticians, and students working with DNA, RNA, and protein sequences.
Most bioinformatics software is either:
I wanted something lightweight, private, and instantly…